Units

Laboratory of Experimental Medicine(CHU Charleroi-Hop Vesale)

Person in charge of the Unit : Oui

The Laboratory of Experimental Medicine is established in a community Hospital, affiliated to the Free University of Brussels; the team is formed by clinicians and researchers, in constant interactivity .The research domains are often choosen to solve observations or problems encountered in clinical practice.Research subjects concern the mechanisms of diseases(atherosclerosis and oxydative stress,sepsis,liver ischemia,cancer,thrombosis,sleep apnea syndrome,COPD,benign prostatic hypertrophy),diagnosis(cardio-vascular diseases),the therapeutic domein(coagulation,inflammation,cardio-vascular stents).The clinicians attached to our laboratory are also involved in clinical education,and want to translate in their clinical approach the lessons of the experimental approach they need in their laboratory work.

Projetcs

Early mechanisms of human atheromatosis

The aim is to understand the early mechanisms of the development of the human atheromatous process,studying interactions  between endothelial cells,coagulation(fibrinolysis),inflammatory triggers like MPO oxydised LDL and the immune system   ; the laboratory has developped an automated and reproducible method of fibriolysis measurement, a model of co-culture (endothelial cells - smooth muscle cells) is now being developped;the laboratory developps a model of endothelial cells  culture exposed to a pulsatile flux;recombinant MPO and antibodies to MPO oxydized  LDL are part of our tools.Owing to his position in a large general hospital,the laboratoty has access to large cohorts of patients,with their biological samples and clinical data, respecting the rules of the ethical commitees.