Units

Biology of the Nucleus

Nuclear pore complexes (NPCs) are large protein assemblies that perforate the double membrane of the nuclear envelope (NE). They mediate all trafficking between the nucleus and the cytoplasm of interphase cells and are composed of a set of different proteins, known as nucleoporins. Nucleoporins frequently have additional functions in, for example, chromatin organisation, transcription and cell cycle progression, which are mainly independent of nuclear transport. Therefore, nucleoporins are key players in overall nuclear organisation and intact nuclear organisation is critical for normal cell function. Our aim is to understand the role of certain nucleoporins in human disease, acute leukaemia and a neuromuscular disorder known as fetal akinesia in particular .

Molecular Cell Physiology

Our research mainly focuses on the yeast S. cerevisiae which is a paradigm model system for dissecting the molecular mechanisms of basic cellular functions in eukaryotes. A wide panel of methods are readily applicable to yeast, ranging from classical genetics and biochemistry to genomics and proteomics. Furthermore, basic cellular mechanisms are highly conserved from yeast to human. This is why some aspects of our work have now been extended to mammals as well.

Projetcs

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