Units

Laboratory of Experimental Neurology

Person in charge of the Unit : Oui

1. Study of the genetic predisposition to epilepsy and to antieplieptic treatment response (pharmacogenetics).2.Investigations on the pathogenesis of Friedreich ataxia and development of new cellular and animal models.3. Development of the induced pluripotent stem cell (iPS) technology for nervous system disease modeling (epilepsy, ataxia). 4. Mechanisms of frataxin gene silencing in Friedreich ataxia and development of therapeutic approaches to restore frataxin gene expression. 5. Investigations on cerebellar physiology and biochemistry by combining microdialysis and neurophysiological recordings on animal models (rodents).

Projetcs

Investigations on the pathogenesis of Friedreich ataxia and development of new animal models.

Analysis of frataxin function and of changes in cellular homeostasis resulting from frataxin deficiency. Utilization of siRNA to generate cellular and animal models of Friedreich ataxia.

1. Study of the genetic predisposition to epilepsy and to antieplieptic treatment response (pharmacogenetics).

Genetic association, gene expression and proteomics studies to investigate the genetic basis of predisposition to epilepsys and to treatment response.