Units

RNA Metabolism

RNA is central stage in gene expression. The 'RNA Metabolism' Lab is trying to understand why all cellular RNAs are working in very close association with proteins within so-called RiboNucleoProtein particles or RNPs. My Lab is interested both in the modes of synthesis and function(s) of the RNPs under normal and disease situations. Defects in the synthesis and/or function(s) of the RNPs irremediably lead to severe human auto-immune and genetic diseases. Our fundamental research therefore has clear biomedical implications. One of our our major experimental paradigm is Eukaryotic Ribosome. These large RNPs are mostly synthesized within a specialized subcellular compartment: the nucleolus. Nucleolar morphogenesis is therefore also of great interest to the Lab. Nucleolar function provide an excellent readout for the overall cellular activity and cancer cells specifically over express nucleolar proteins which are thus potent markers for diagnosis and prognosis. Our research also focuses on these nucleolar proteins.

Laboratory of Neurovascular Signaling

Our goal is to understand how the vascular and neural systems dynamically communicate to orchestrate brain development and function. It is now clear that blood vessels are more than passive conduits for blood flow and that tissue-specific vascular beds not only match the metabolic demands of the perfused organs but also act as important signaling centers releasing angiocrine factors that govern tissue morphogenesis and function. Proper brain function relies on elaborate neurovascular communications that, when perturbed, often have disabling or fatal consequences. Hence, there is great interest in studying the mechanisms that shape the anatomy and control the functionality of the cerebrovasculature, not only to better understand how the brain develops and works, but also to elaborate innovative therapeutic strategies for neurological disorders. We leverage the zebrafish brain as a normoxic and transparent setting to explore CNS neurovascular interactions in real time and at single-cell resolution in order to better understand through which cellular and molecular mechanisms CNS vascular invasion and maturation are controlled by neural signals and, reciprocally, how the developing vascular system impacts brain patterning and function.In addition, our laboratory contains two independent research sub-units studying molecular parasitology and inflammation molecular biology.

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