Units

Laboratory of Clinical Cell Therapy

Our laboratory is dedicated to the fundamental and translational research in the domain of Immunology and hematology. Several research themes are approached and the laboratory works in symbiosis with the Clinical Hematology Departement of Jules Bordet Insitute.The laboratory competences, staff and equipment allows the realization of clinical and fundamental research projects according to various approaches: cellular biology, immunology, molecular biology and cell therapy.From several years, our laboratory is interested in the bone marrow microenvironment, its regulation and the abnormalities observed at this level in diverse pathologies (particularly in chronic lymphocytic leukemia and multiple myeloma).More recently, we study particularly mesenchymal stromal cells at the level of source, phenotype, expansion, plasticity, pro-hematopoietic activity and immunomodulation. Other research areas are also clinical and concern hematopoietic stem cell transplantation and their in vitro amplification, mesenchymal stromal cell infusion to accelerate hematopoietic cell recovery and to prevent GVHD, and cell therapy.

Laboratory of Experimental Hematology

Person in charge of the Unit : Oui

Dedicated to applied and fundamental research, the Laboratory of Experimental Hematology is articulated around three main subjects: 1. study of the inhibition mechanisms of cancer cells rejection by the immune system to better understand how the tumoral microenvironement support and allow the growth of leukemic cells;2. discovery of new tumoral environment biomarkers predictive of patient prognosis and treatments response;3. study of the role of non-coding RNA in oncogenesis in a viro-induced leukemia model.Today, in most of the case, the autologus system is unable to eradicate residual leukemic cells that escape radio-chemotherapy. The high relapse rate in cancers gives evidence of this inefficacy of the immune system to control residual cancer cells. Therefore, the current issue is to understand the immune environment of cancer and the interactions between cancer cells and the immune system. A particular aspect is the understanding of the mechanisms leading to the generation, in the context of leukemia, of T regulatory lymphocytes. regulatory T cells are actively engaged in the maintenance of immunological tolerance by suppressing reactive T cells. The use of a viro-induced leukemic model allows us to unveiled molecular mechanisms potentially involved in tumor progression. All these knowledge are critical to discover optimal immune-modulation modalities to obtain a powerful and sustained anticancer effect.

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