Units

Biology of Membrane Transport Laboratory
The team is actively engaged in investigations regarding the translocation of ions and other solutes across cell membranes. Unicellular and multicellular models are used to evaluate the links between transport, metabolism and physiology, with a particular interest in the mechanisms and interactions regulating transmembrane ammonium movements. Ammonium is ubiquitous in nature and has a general importance. It is a principal nitrogen source for micro-organisms and plants, and a cytotoxic metabolite of most animal cells. Sophisticated detoxification and elimination pathways have been developed during evolution to prevent its excessive accumulation. The majority of the projects in the Biology of Membrane Transport Laboratory address the role of Mep-Amt-Rhesus transport proteins in the acquisition and the disposal of ammonium in the baker yeast and the mouse. Defects in Rhesus factors are so far related to known human pathologies affecting red blood cells, kidney function and male fertility. Ongoing studies in the laboratory are seeking to identify new connections linking Rhesus factors dysfunction and human diseases, with a specific concern for a potential role of these proteins in ammonium homeostasis and pH regulation of physiological fluids. By investigating the biogenesis, structure, trafficking, kinetics and regulation of these transport proteins, we hope to advance our understanding of these disorders with the prospect of potential therapeutic interventions.
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