Intraperitoneal administration of 2ME on day 10 and day 10 + 6H of a 10 mM/kg doseinduce skeletal fetal malformations (limbs and
spine).  Microscopic study showed alterations of the notochord, of the sclerotome derivatives, neural tube deformities and vascular
dilatations.  Identification of the critical dose and time of administration is necessary before examine the mechanisms of
teratogenesis